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Chromosome aberrations among the children of atomic-bomb survivors (1967-1985) |
Extensive chromosome analyses have been done in F1 offspring of A-bomb survivors to determine if radiation-induced stable
aberrations in parental germ cells (reciprocal translocations and inversions).
No evidence was found to suggest increased F1 aberrations.
Studies compared 8,322 persons with one or both parents within 2,000 meters
of the hypocenters (estimated doses of 0.01 Gy or more) and 7,976 persons
with parents beyond 2,500 meters (doses less than 0.005 Gy) or not in the
cities ATB. Eighteen persons in the exposed group and 25 controls carried
stable aberrations (Table). Tests of parents and siblings showed that most
aberrations were pre-existing and inherited from one parent. Only one from
each group had a newly arisen aberration. The origin of aberrations in
16 cases could not be determined because parents had either died or did
not wish to participate in the study. Dose distributions, however, were
similar in tested and untested parents.
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Table. Stable chromosome aberrations in children of A-bomb survivors
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Origin of aberrations
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Children with aberrations
|
Control group
（7,976 children） |
Exposed group*
（8,322 children） |
|
| Newly arisen
|
1（0.01%）
|
1（0.01%） |
| Inherited from either parent |
15（0.19%）
|
10（0.12%） |
| Parental origin untested |
9（0.11%）
|
7（0.08%） |
| Total |
25（0.31%）
|
18（0.22%） |
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Reference about this subject
 |
Neel JV, Schull WJ, et al.: The children of parents exposed to atomic bombs:
Estimates of the genetic doubling dose of radiation for humans. Journal
of Radiation Research (Tokyo) 1991; 32(Suppl):347-74. (A review of 45 years' study of Hiroshima and Nagasaki atomic-bomb survivors) |
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